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Andrew N Billin Selected Research

cilofexor

6/2022IL-31 levels correlate with pruritus in patients with cholestatic and metabolic liver diseases and is farnesoid X receptor responsive in NASH.
1/2022Safety and efficacy of combination therapy with semaglutide, cilofexor and firsocostat in patients with non-alcoholic steatohepatitis: A randomised, open-label phase II trial.
1/2020Cilofexor, a Nonsteroidal FXR Agonist, in Patients With Noncirrhotic NASH: A Phase 2 Randomized Controlled Trial.
1/2019The Nonsteroidal Farnesoid X Receptor Agonist Cilofexor (GS-9674) Improves Markers of Cholestasis and Liver Injury in Patients With Primary Sclerosing Cholangitis.

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Andrew N Billin Research Topics

Disease

6Fibrosis (Cirrhosis)
12/2022 - 01/2019
4Neoplasms (Cancer)
01/2022 - 12/2007
4Carcinogenesis
01/2008 - 04/2006
3Non-alcoholic Fatty Liver Disease
12/2022 - 01/2020
3Inflammation (Inflammations)
05/2008 - 11/2007
2Sclerosing Cholangitis
06/2022 - 01/2019
2Pruritus (Itching)
06/2022 - 01/2020
2Fatty Liver
01/2022 - 01/2020
2Liver Cirrhosis (Hepatic Cirrhosis)
01/2021 - 01/2020
2Type 2 Diabetes Mellitus (MODY)
10/2008 - 08/2007
2Dyslipidemias (Dyslipidemia)
10/2008 - 08/2007
2Colonic Neoplasms (Colon Cancer)
01/2008 - 04/2006
2Polyps
12/2007 - 04/2006
1Disease Progression
12/2022
1Biliary Liver Cirrhosis (Primary Biliary Cirrhosis)
06/2022
1Rheumatoid Arthritis
01/2022
1Alcoholic Fatty Liver
01/2022
1Weight Loss (Weight Reduction)
01/2022
1Inflammatory Bowel Diseases (Inflammatory Bowel Disease)
01/2019
1Cholestasis
01/2019
1Hypoxia (Hypoxemia)
11/2018
1Sarcoma (Soft Tissue Sarcoma)
11/2014
1Genetic Translocation (Chromosomal Translocation)
11/2014
1Rhabdomyosarcoma
11/2014
1Cardiac Arrhythmias (Arrythmia)
02/2010
1Breast Neoplasms (Breast Cancer)
01/2008
1Melanoma (Melanoma, Malignant)
01/2008
1Obesity
01/2008
1Metabolic Syndrome (Dysmetabolic Syndrome X)
01/2008
1Colorectal Neoplasms (Colorectal Cancer)
01/2008
1Insulin Resistance
12/2007
1Colitis
11/2007
1Body Weight (Weight, Body)
11/2007
1Leukemia
05/2007

Drug/Important Bio-Agent (IBA)

8PPAR-betaIBA
10/2008 - 04/2006
7LigandsIBA
02/2008 - 04/2006
4Bile Acids and Salts (Bile Acids)IBA
12/2022 - 01/2019
4cilofexorIBA
06/2022 - 01/2019
4Peroxisome Proliferator-Activated Receptors (PPAR)IBA
01/2008 - 04/2006
4(4- (((2- (3- fluoro- 4- (trifluoromethyl)phenyl)- 4- methyl- 1,3- thiazol- 5- yl)methyl)sulfanyl)- 2- methylphenoxy)acetic acidIBA
01/2008 - 11/2007
3Biomarkers (Surrogate Marker)IBA
12/2022 - 01/2020
2Pharmaceutical PreparationsIBA
01/2022 - 10/2021
2Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
11/2018 - 12/2007
2GW 501516IBA
01/2008 - 12/2007
2Cyclooxygenase 2 (Cyclooxygenase-2)IBA
01/2008 - 12/2007
2PPAR gammaIBA
11/2007 - 08/2007
116S Ribosomal RNAIBA
12/2022
1Glycodeoxycholic AcidIBA
12/2022
1AcidsIBA
12/2022
1Deoxycholic Acid (Sodium Deoxycholate)IBA
12/2022
1Dehydrocholic Acid (Sodium Dehydrocholate)IBA
12/2022
1Hydroxysteroid DehydrogenasesIBA
12/2022
1choloylglycine hydrolaseIBA
12/2022
1semaglutideIBA
01/2022
1tirabrutinibIBA
01/2022
1firsocostatIBA
01/2022
1Agammaglobulinaemia Tyrosine KinaseIBA
01/2022
1Peptides (Polypeptides)IBA
10/2021
1Peptide Hydrolases (Proteases)FDA Link
10/2021
1RNA (Ribonucleic Acid)IBA
01/2021
1Biological ProductsIBA
01/2021
1CollagenIBA
01/2021
1Interleukin-8 (Interleukin 8)IBA
01/2021
1gamma-Glutamyltransferase (gamma-Glutamyl Transpeptidase)IBA
01/2020
1Ursodeoxycholic Acid (Urso)FDA LinkGeneric
01/2019
1Oxygen (Dioxygen)IBA
11/2018
1DNA (Deoxyribonucleic Acid)IBA
11/2014
1PotassiumIBA
02/2010
1delta Opioid Receptors (delta Opioid Receptor)IBA
02/2008
1Prostaglandins EIBA
01/2008
1ProstaglandinsIBA
01/2008
1nimesulide (Aulin)IBA
01/2008
1Prostaglandin-Endoperoxide Synthases (Cyclooxygenase)IBA
01/2008
1AzoxymethaneIBA
01/2008
1Fatty Acids (Saturated Fatty Acids)IBA
12/2007
1HDL CholesterolIBA
12/2007
1Dextrans (Dextran)FDA Link
11/2007
1sodium sulfate (sodium bisulfate)FDA LinkGeneric
11/2007
1Interferon-gamma (Interferon, gamma)IBA
11/2007
1Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
11/2007
1Interleukin-6 (Interleukin 6)IBA
11/2007
1Peroxidase (Myeloperoxidase)IBA
11/2007
1PPAR alphaIBA
08/2007
1Tretinoin (Retinoic Acid)FDA LinkGeneric
05/2007
1Retinoic Acid Receptor alphaIBA
05/2007
1Cathepsin EIBA
04/2006

Therapy/Procedure

4Therapeutics
12/2022 - 11/2014